{"id":3124,"date":"2021-04-11T09:15:22","date_gmt":"2021-04-11T09:15:22","guid":{"rendered":"https:\/\/www.registrotumoriveneto.it\/2021\/04\/11\/a-comprehensive-assessment-of-the-impact-of-a-colorectal-cancer-screening-program-in-a-northern-italian-area\/"},"modified":"2021-04-11T09:15:22","modified_gmt":"2021-04-11T09:15:22","slug":"a-comprehensive-assessment-of-the-impact-of-a-colorectal-cancer-screening-program-in-a-northern-italian-area","status":"publish","type":"post","link":"https:\/\/www.registrotumoriveneto.it\/en\/english\/publications\/research-publications\/2021\/a-comprehensive-assessment-of-the-impact-of-a-colorectal-cancer-screening-program-in-a-northern-italian-area\/","title":{"rendered":"A comprehensive assessment of the impact of a colorectal cancer screening program in a northern Italian area"},"content":{"rendered":"

Pancheri S, Pertile R, Armelao F, Rizzello RV, Piffer S, Zorzi M, Guzzinati S, Ferro A, Mantovani W, de Pretis G.<\/em><\/p>\n

Dig Liver Dis. 2021 Apr 11:S1590-8658(21)00130-4. doi: 10.1016\/j.dld.2021.03.016. Online ahead of print.<\/em><\/p>\n

<\/p>\n

\u00a0Abstract<\/strong><\/p>\n

Background: The impact of a faecal immunochemical test-based colorectal cancer (CRC) screening program in terms of patient prognosis could be affected by lead-time bias, which artificially increases the survival of screen-detected patients due to the early diagnosis.<\/p>\n

Aims: To provide a description of the impact of the CRC screening program in the Trentino Region (Italy), including the Cure Fraction (CF), a prognostic indicator not affected by lead-time bias.<\/p>\n

Methods: The program started in 2008, inviting the resident population aged 50-69 years. In this retrospective cohort study, 1,697 CRC diagnosed between 2003 and 2014 in patients aged 50-69 years were classified as pre-screening (PS), screen-detected (SD), interval cancers (IC) and not-screen-detected (NSD). We compared groups by stage at diagnosis and CF. Trends in CRC mortality were reported.<\/p>\n

Results: The proportion of stage I among SD cases was 51%, higher than PS (19%; OR 4.66, 95%CI 3.50-6.20), NSD (20.6%; OR 3.96, 95%CI 2.95-5.32) and IC (33.3%; OR 2.11, 95%CI 1.10-4.04). The CF of PS, NSD and SD cases was respectively 57% (95%CI 54-60%), 60% (95%CI 58-63%) and 93% (95%CI 89-96%). CRC mortality dropped from 40.7 to 25.6\\100,000.<\/p>\n

Conclusion: The program significantly improved the prognosis of patients, decreasing CRC mortality and incidence of advanced CRCs.<\/p>\n

Pubmed\u00a0<\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/33853757\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Pancheri S, Pertile R, Armelao F, Rizzello RV, Piffer S, Zorzi M, Guzzinati S, Ferro A, Mantovani W, de Pretis G. Dig Liver Dis. 2021 Apr 11:S1590-8658(21)00130-4. doi: 10.1016\/j.dld.2021.03.016. Online ahead of print.<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_helpful_status":1,"footnotes":""},"categories":[399,724,746,796,887,888],"tags":[],"class_list":["post-3124","post","type-post","status-publish","format-standard","hentry","category-399","category-colorectal-cancer-screening","category-faecal-immunochemical-test","category-mortality","category-venetotumour-registry-colorectal-cancer","category-venetotumour-registry-incidence"],"yoast_head":"\nRegistro Tumori Veneto — A comprehensive assessment of the impact of a colorectal cancer screening program in a northern Italian area<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.registrotumoriveneto.it\/en\/english\/publications\/research-publications\/2021\/a-comprehensive-assessment-of-the-impact-of-a-colorectal-cancer-screening-program-in-a-northern-italian-area\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Registro Tumori Veneto — A comprehensive assessment of the impact of a colorectal cancer screening program in a northern Italian area\" \/>\n<meta property=\"og:description\" content=\"Pancheri S, Pertile R, Armelao F, Rizzello RV, Piffer S, Zorzi M, Guzzinati S, Ferro A, Mantovani W, de Pretis G. 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