{"id":3078,"date":"2020-06-05T06:00:00","date_gmt":"2020-06-05T06:00:00","guid":{"rendered":"https:\/\/www.registrotumoriveneto.it\/2020\/06\/05\/colonoscopy-later-than-270-days-in-a-fecal-immunochemical-test-based-population-screening-program-is-associated-with-higher-prevalence-of-colorectal-cancer\/"},"modified":"2020-06-05T06:00:00","modified_gmt":"2020-06-05T06:00:00","slug":"colonoscopy-later-than-270-days-in-a-fecal-immunochemical-test-based-population-screening-program-is-associated-with-higher-prevalence-of-colorectal-cancer","status":"publish","type":"post","link":"https:\/\/www.registrotumoriveneto.it\/en\/english\/publications\/research-publications\/2020\/colonoscopy-later-than-270-days-in-a-fecal-immunochemical-test-based-population-screening-program-is-associated-with-higher-prevalence-of-colorectal-cancer\/","title":{"rendered":"Colonoscopy later than 270 days in a fecal immunochemical test-based population screening program is associated with higher prevalence of colorectal cancer"},"content":{"rendered":"

Zorzi M, Hassan C, Capodaglio G, Baracco M, Antonelli G, Bovo E, Rugge M.<\/em><\/p>\n

Endoscopy. 2020 Apr 30. doi: 10.1055\/a-1159-0644. Online ahead of print.<\/em><\/p>\n

<\/p>\n

\u00a0<\/p>\n

Abstract<\/strong><\/p>\n

BACKGROUND : Colorectal cancer (CRC) screening programs based on fecal immunochemical testing (FIT) generate substantial pressure on colonoscopy capacity in Europe. Thus, a relevant proportion of FIT-positive patients undergo colonoscopy after the recommended 30-day interval, which may be associated with an excess CRC risk. METHODS : In a cohort of 50-69-year-old patients undergoing biennial rounds of FIT (OC-Hemodia latex agglutination test; cutoff 20 \u00b5g hemoglobin\/g feces) between 2004 and 2017, we assessed the outcome at colonoscopy (low\/high risk adenoma\/CRC\/advanced stage CRC) among FIT-positive patients, according to different time intervals. The association of each outcome with waiting time, and demographic and clinical factors, was analyzed through multivariable analysis. RESULTS : 123 138\/154 213 FIT-positive patients (79.8 %) underwent post-FIT colonoscopy. Time to colonoscopy was \u2264 30 days, 31-180 days, and \u2265 181 days in 50 406 (40.9 %), 71 724 (58.3 %), and 1008 (0.8 %) patients, respectively. At colonoscopy, CRC, high risk adenoma, and low risk adenoma were diagnosed in 4813 (3.9 %), 30 500 (24.8 %), and 22 986 (18.7 %) patients, respectively. An increased CRC prevalence at colonoscopy was observed for a time to colonoscopy of \u2265 270 days (odds ratio [OR] 1.75, 95 % confidence interval [CI] 1.15-2.67), whereas it was stable for waiting times of < 180 days. The proportion of advanced CRC also increased after 270 days (OR 2.79, 95 %CI 1.03-7.57). No increase for low or high risk adenomas according to time to colonoscopy was observed. CONCLUSION : In a European FIT-based screening program, post-FIT colonoscopy after 9 months was associated with an increased risk of CRC and CRC progression.<\/p>\n

\u00a9 Georg Thieme Verlag KG Stuttgart \u00b7 New York.<\/p>\n

\u00a0\u00a0<\/p>\n

Pubmed:<\/strong> https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32273199<\/a><\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

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