Zorzi M, Mangone L, Anghinoni E, Baracco S, Borciani E, Caldarella A, Falcini F, Fanetti AC, Ferretti S, Giorgi Rossi P, Michiara M, Randi G, Stracci F, Vicentini M, Zucchetto A, Zappa M and IMPATTO COLONRETTO working group.

Epidemiol Prev 2015; 39(3) Suppl 1:108-14



The impact of organized screening programmes on colorectal cancer (CRC) can be observed at a population level only several years after the implementation of screening. We compared CRC characteristics by diagnostic modality (screen-detected, non-screen-detected) as an early outcome to monitor screening programme effectiveness. Data on CRCs diagnosed in Italy from 2000 to 2008 were collected by several cancer registries. Linkage with screening datasets made it possible to divide the cases by geographic area, implementation of screening, and modality of diagnosis (screen-detected, non-screen-detected). We compared the main characteristics of the different subgroups of CRCs through multivariate logistic regression models.
The study included 23,668 CRCs diagnosed in subjects aged 50-69 years, of which 11.9% were screendetected (N=2,806), all from the North-Centre of Italy. Among screen-detected CRCs, we observed a higher proportion of males, of cases in the distal colon, and a higher mean age of the patients. Compared with pre-screening cases, screen-detected CRCs showed a better distribution by stage at diagnosis (OR for stage III or IV: 0.40, 95%CI: 0.36-0.44) and grading (OR for poorly Differentiated CRCs was 0.86, 95%CI: 0.75-1.00).
Screen-detected CRCs have more favourable prognostic characteristics than non-screen-detected cases. A renewed effort to implement screening programmes throughout the entire country is recommended.


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