The procedures for identifying, collecting, defining, classifying, and coding cases, and patients’ stories of exposure to asbestos - the main risk factor for mesothelioma - are defined by national guidelines.

The diagnosis of mesothelioma is particularly difficult due to the complex features of this disease (low incidence, histological picture, etc.), and that is why a reference protocol was developed to classify cases by the level of diagnostic certainty.

The occupational history of each patient with mesothelioma is assessed by means of a standard questionnaire administered directly to the individuals affected (if still alive), or to their relatives. To gather data relating to any history of exposure to asbestos, the Registry collaborates with the Local Health Units’ Services for Prevention, Hygiene and Safety in the Workplace (SPISAL).